Cov kws tshawb fawb tau tsim lub platform rau kev sib sau cov khoom siv nanosized, lossis "nano-cov khoom," ntawm ntau hom - inorganic lossis organic - rau hauv cov qauv 3-D uas xav tau.Txawm hais tias nws tus kheej-assembly (SA) tau ua tiav tau siv los npaj cov khoom siv nano ntawm ntau yam, cov txheej txheem tau ua haujlwm tshwj xeeb, tsim cov qauv sib txawv raws li cov khoom siv hauv cov khoom siv.Raws li tau tshaj tawm nyob rau hauv ib daim ntawv luam tawm niaj hnub no hauv Cov Khoom Siv Xwm Txheej, lawv cov DNA tshiab-programmable nanofabrication platform tuaj yeem siv los npaj ntau yam 3-D cov ntaub ntawv hauv tib txoj hauv kev ntawm nanoscale (billionths ntawm ib lub meter), qhov tshwj xeeb kho qhov muag, tshuaj. , thiab lwm yam khoom tshwm sim.
"Ib qho ntawm cov laj thawj tseem ceeb vim li cas SA tsis yog cov txheej txheem ntawm kev xaiv rau kev siv tswv yim yog tias tib txoj kev SA tsis tuaj yeem siv thoob plaws ntau yam khoom siv los tsim cov 3-D xaj arrays los ntawm ntau cov nanocomponents," piav qhia tus sau Oleg Gang. , tus thawj coj ntawm Soft and Bio Nanomaterials Group ntawm Center for Functional Nanomaterials (CFN) - US Department of Energy (DOE) Office of Science User Facility ntawm Brookhaven National Laboratory - thiab ib tug xibfwb ntawm Chemical Engineering thiab Applied Physics thiab Materials Science ntawm Columbia Engineering."Ntawm no, peb decoupled SA cov txheej txheem los ntawm cov khoom siv los ntawm kev tsim cov kab nrib polyhedral DNA uas tuaj yeem ua rau ntau yam inorganic lossis organic nano-cov khoom, suav nrog cov hlau, semiconductors, thiab txawm tias cov proteins thiab enzymes."
Cov kws tshawb fawb tau tsim cov qauv DNA hluavtaws hauv cov duab ntawm lub voos xwmfab, octahedron, thiab tetrahedron.Hauv cov thav ntawv yog DNA "arms" uas tsuas yog cov khoom nano nrog cov DNA sib txuas ntxiv tuaj yeem khi rau.Cov khoom siv voxels - kev koom ua ke ntawm DNA thav duab thiab nano-khoom - yog lub tsev thaiv los ntawm cov qauv macroscale 3-D tuaj yeem ua.Cov thav ntawv txuas mus rau ib leeg txawm hais tias hom nano-khoom yog dab tsi nyob hauv (lossis tsis) raws li kev sib txuas ua ke lawv tau encoded nrog ntawm lawv cov vertices.Nyob ntawm lawv cov duab, thav ntawv muaj ntau qhov sib txawv ntawm cov vertices thiab yog li tsim cov qauv sib txawv.Txhua yam khoom nano-cov khoom tuav hauv lub thav duab coj mus rau qhov tshwj xeeb thav duab qauv.
Txhawm rau ua kom pom lawv txoj kev sib dhos, cov kws tshawb fawb tau xaiv cov khoom siv hlau (kub) thiab semiconducting (cadmium selenide) nanoparticles thiab cov kab mob protein (streptavidin) ua cov khoom tsis muaj zog thiab cov organic nano-cov khoom yuav tsum tau muab tso rau hauv DNA thav duab.Ua ntej, lawv tau lees paub qhov ncaj ncees ntawm DNA thav duab thiab tsim cov khoom siv voxels los ntawm kev thaij duab nrog lub tshuab ntsuas hluav taws xob ntawm CFN Electron Microscopy Facility thiab Van Andel Institute, uas muaj cov cuab yeej siv ua haujlwm ntawm qhov kub thiab txias rau cov qauv lom neeg.Tom qab ntawd lawv tau soj ntsuam cov qauv 3-D lattice ntawm Coherent Hard X-ray Scattering thiab Complex Materials Scattering beamlines ntawm National Synchrotron Light Source II (NSLS-II) - lwm DOE Lub Chaw Haujlwm Saib Xyuas Kev Tshawb Fawb ntawm Brookhaven Lab.Columbia Engineering Bykhovsky tus xibfwb ntawm Chemical Engineering Sanat Kumar thiab nws pab pawg tau ua cov qauv kev ua qauv qhia pom tias qhov kev sim pom cov qauv lattice (raws li cov qauv x-ray tawg) yog cov thermodynamically ruaj khov tshaj plaws uas cov khoom siv voxels tuaj yeem tsim.
"Cov ntaub ntawv voxels tso cai rau peb pib siv cov tswv yim muab los ntawm atoms (thiab molecules) thiab cov crystals uas lawv tsim, thiab xa cov kev paub dav dav thiab cov ntaub ntawv mus rau cov kev txaus siab ntawm nanoscale," piav qhia Kumar.
Gang cov tub ntxhais kawm ntawm Columbia tom qab ntawd ua qauv qhia yuav ua li cas lub rooj sib txoos tuaj yeem siv los tsav lub koom haum ntawm ob yam khoom sib txawv nrog cov khoom siv tshuaj thiab kho qhov muag.Nyob rau hauv ib rooj plaub, lawv tau sib sau ua ke ob enzymes, tsim 3-D arrays nrog ib tug siab packing ceev.Txawm hais tias cov enzymes tseem tsis tau hloov pauv, lawv tau pom txog plaub npaug ntawm kev ua haujlwm enzymatic.Cov "nanoreactors" no tuaj yeem siv los tswj cov kev cuam tshuam cascade thiab pab tsim cov khoom siv tshuaj lom neeg.Rau cov khoom siv kho qhov muag pom, lawv sib xyaw ob xim sib txawv ntawm quantum dots - me me nanocrystals uas tau siv los ua TV qhia nrog cov xim siab thiab ci ntsa iab.Cov duab ntes nrog lub fluorescence microscope pom tias cov lattice tsim tau khaws cov xim purity hauv qab qhov kev txwv tsis pub tshaj (wavelength) ntawm lub teeb;Cov cuab yeej no tuaj yeem tso cai rau kev txhim kho kev daws teeb meem tseem ceeb hauv ntau yam khoom siv thiab kev sib txuas lus kho qhov muag.
"Peb yuav tsum rov xav dua yuav ua li cas cov ntaub ntawv tuaj yeem tsim tau thiab lawv ua haujlwm li cas," Gang hais."Cov ntaub ntawv rov tsim dua tshiab yuav tsis tsim nyog; tsuas yog ntim cov ntaub ntawv uas twb muaj lawm hauv txoj hauv kev tshiab tuaj yeem txhim kho lawv cov khoom. Muaj peev xwm, peb lub platform tuaj yeem yog ib qho kev siv thev naus laus zis 'tshaj li 3-D luam ntawv tsim' los tswj cov khoom ntawm ntau qhov me me thiab nrog cov khoom siv ntau dua thiab Siv tib txoj hauv kev los tsim 3-D lattices los ntawm kev xav tau nano-khoom ntawm cov khoom siv sib txawv, kev sib xyaw ua ke uas yuav suav tias yog tsis sib xws, tuaj yeem hloov kho nanomanufacturing. "
Cov ntaub ntawv muab los ntawm DOE / Brookhaven National Laboratory.Nco tseg: Cov ntsiab lus tuaj yeem hloov kho rau style thiab ntev.
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Post lub sij hawm: Jan-14-2020