Ua atia'e e Saienitisi se fa'avae mo le fa'apipi'iina o vaega meafaitino fa'anosized, po'o "mea-nano," e matua'i 'ese'ese ituaiga -- e le fa'aletino po'o le fa'aola -- i totonu o fausaga 3-D mana'omia. E ui lava o le faʻapipiʻiina o le tagata lava ia (SA) ua faʻaaogaina lelei e faʻatulaga ai nanomaterials o le tele o ituaiga, o le faagasologa ua matua faʻapitoa-faʻapitoa, faʻatupuina fausaga eseese e faʻavae i luga o mea totino o meafaitino. E pei ona lipotia mai i se pepa na lolomiina i aso nei i Nature Materials, o la latou DNA-programmable nanofabrication platform e mafai ona faʻaogaina e faʻapipiʻi ai le tele o mea 3-D i auala tutusa i le nanoscale (billionths o le mita), lea e tulaga ese ai mata, vailaʻau. , ma isi meatotino ua aliali mai.
"O se tasi o mafuaʻaga autu e le o se auala e filifili ai le SA mo faʻaoga faʻaoga e le mafai ona faʻaogaina le faiga tutusa o le SA i luga o le lautele o meafaitino e fatu ai faʻatonuga tutusa 3-D mai nanocomponents eseese," o le tala lea a le tusitala o Oleg Gang. , taitai o le Soft and Bio Nanomaterials Group i le Center for Functional Nanomaterials (CFN) -- a US Department of Energy (DOE) Office of Science User Facility i Brookhaven National Laboratory -- ma se polofesa o Inisinia Kemisi ma le Fa'aaogaina o le Physics and Materials Science i Columbia Engineering. "O iinei, matou te vavaeeseina le faagasologa o le SA mai meafaitino e ala i le mamanuina o faʻamalama DNA polyhedral e mafai ona faʻapipiʻi eseese mea faʻapitoa poʻo meaola nano-mea, e aofia ai metala, semiconductor, ma e oʻo lava i polotini ma enzymes."
Sa fa'ainisinia e le au saienitisi fa'avaa DNA fa'atusa i foliga o se kupita, octahedron, ma le tetrahedron. I totonu o fa'ava'a o lo'o iai "lima" DNA e na'o mea nano-mea fa'atasi ma le fa'asologa DNA e mafai ona fusifusia i ai. O mea nei voxels -- o le tu'ufa'atasiga o le fa'avaa DNA ma le nano-mea - o poloka faufale ia e mafai ai ona fa'atūina fa'asologa 3-D macroscale. O fa'avaa e feso'ota'i le tasi i le isi e tusa lava po'o le a le ituaiga nano-mea o lo'o i totonu (pe leai) e tusa ai ma fa'asologa fa'atasi o lo'o fa'apipi'iina i o latou pito. Fa'alagolago i o latou foliga, o fa'avaa e ese le aofa'i o vertices ma fa'atupu ai le fa'atupu ese'ese atoa. So'o se nano-meafaitino e fa'afeiloa'i i totonu o fa'avaa e ave i luga o lena fa'atulagaga fa'avaa ma'oti.
Ina ia faʻaalia la latou faʻapotopotoga, na filifilia e saienitisi nanoparticles (auro) ma semiconducting (cadmium selenide) ma se polotini siama (streptavidin) e avea ma mea faʻapitoa ma mea faʻaletino e tuʻu i totonu o le DNA. Muamua, na latou faʻamaonia le faʻamaoni o le DNA faʻavae ma le faʻavaeina o mea voxels e ala i ata faʻatasi ma microscopes electron i le CFN Electron Microscopy Facility ma le Van Andel Institute, o loʻo i ai se seti o meafaifaʻaili e faʻaogaina i le vevela o le cryogenic mo faʻataʻitaʻiga o meaola. Ona latou su'esu'eina lea o fausaga lattice 3-D i le Coherent Hard X-ray Scattering and Complex Materials Scattering beamlines o le National Synchrotron Light Source II (NSLS-II) -- seisi DOE Office of Science User Facility i Brookhaven Lab. Columbia Engineering Bykhovsky Polofesa o Chemical Engineering Sanat Kumar ma lana vaega na faia le faʻataʻitaʻiga faʻatusatusaga e faʻaalia ai o le faʻataʻitaʻiga o le lattice structures (faʻavae i luga o le x-ray faʻataʻapeʻapeina mamanu) o mea aupito sili ona mautu le thermodynamic e mafai ona fausia e le voxels.
"O nei mea voxels e mafai ai ona tatou amata faʻaaoga manatu e maua mai i atoms (ma mole) ma tioata latou te faia, ma faʻafeiloaʻi lenei malamalama tele ma faʻamaumauga i faiga e fiafia i ai i le nanoscale," o le faʻamatalaga lea a Kumar.
Na fa'aalia e tamaiti a'oga a Gang i Columbia pe fa'apefea ona fa'aogaina le fa'aputuga fa'apotopotoga e fa'atūina ai le fa'atulagaina o ituaiga mea eseese e lua e iai le vaila'au ma galuega fa'atino. I se tasi tulaga, na latou faʻapipiʻi faʻatasi ni enzymes se lua, fatuina 3-D arrays ma le maualuga o le faʻapipiʻiina. E ui ina sa tumau pea le le suia o vailaʻau, ae na faʻaalia le faʻateleina o le gaioiga o le enzymatic. O nei "nanoreactors" e mafai ona fa'aogaina e fa'aogaina ai fa'alavelave fa'afuase'i ma mafai ai ona fa'atupu mea fa'a kemikolo. Mo le fa'ata'ita'iga o mea fa'apitoa, na fa'afefiloi ai lanu 'ese'ese se lua o togitogi fa'atauva'a -- tama'i nanocrystals o lo'o fa'aaogaina e fai ai fa'aaliga televise e maualuga le lanu ma le susulu. O ata na pu'eina i se microscope fluorescence na fa'aalia ai o le lattice na faia na fa'atumauina le mama o lanu i lalo ifo o le fa'atapula'aina (umi o galu) o le malamalama; o lenei meatotino e mafai ona fa'ataga mo le fa'aleleia atili o fa'ai'uga i fa'aaliga eseese ma feso'ota'iga feso'ota'iga.
"E manaʻomia ona tatou toe mafaufau pe faʻapefea ona fausia mea ma pe faʻafefea ona faʻaogaina," o le tala lea a Gang. "Atonu e le manaʻomia le toe faʻaleleia o meafaitino; naʻo le faʻapipiʻiina o mea o loʻo i ai i ni auala fou e mafai ona faʻaleleia atili ai a latou meatotino. E ono mafai, o la tatou faʻavae e mafai ona avea ma tekinolosi faʻaagaoioia 'i tua atu o le gaosiga o lomitusi 3-D' e pulea ai mea i fua laʻititi laʻititi ma sili atu mea eseese ma Fa'aaogāina o le auala lava e tasi e fa'atupu ai lattices 3-D mai mea e mana'omia nano-mea eseese vasega, tu'ufa'atasia i latou e ono manatu e le fetaui, e mafai ona fa'afouina. nanomanufacturing."
Mea e saunia e le DOE/Brookhaven National Laboratory. Fa'aaliga: E mafai ona fa'asa'o mea mo le sitaili ma le umi.
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Taimi meli: Ian-14-2020