Mumakore achangopfuura, nano-zvinodhaka tekinoroji ndiyo yakakurumbira tekinoroji mukugadzira zvinodhaka tekinoroji. Nano zvinodhaka zvakadai se nanoparticles, bhora kana nano capsule nanoparticles semutakuri wehurongwa, uye kushanda kwezvikamu mune imwe nzira pamwe chete mushure memushonga, zvinogonawo kuitwa zvakananga kune unyanzvi hwekugadzirisa nanoparticles.
Kuenzaniswa nemishonga yakajairika, nano-zvinodhaka zvine zvakawanda zvakanakira zvisingaenzaniswi nemishonga yakajairika:
Mushonga unononoka kusunungurwa, kushandura hafu yeupenyu hwemushonga mumuviri, kuwedzera nguva yekuita kwechirwere;
Imwe nhengo yakananga inogona kusvikwa mushure mekugadzirwa mushonga unotungamirirwa;
Kudzikisa dosi, dzikisa kana kubvisa chepfu mhedzisiro pasi pechimiro chekuona kushanda;
Iyo membrane yekufambisa nzira inoshandurwa kuti iwedzere kupera kwemushonga kune biofilm, iyo inobatsira kune zvinodhaka transdermal absorption uye kutamba kwemushonga unoshanda.
Saka kune izvo zvinodiwa nerubatsiro rwemutakuri kuendesa mishonga kune zvakananga zvinangwa, kupa kutamba kune basa rekurapa maererano nanodrugs, dhizaini yemutakuri yekuvandudza mashandiro ekunangwa kwezvinodhaka kwakakosha.
Munguva pfupi yapfuura pepanhau renhau rakati yunivhesiti yeNew South Wales, Australia, vatsvakurudzi vakagadzira nzira itsva, inogona kuchinja chimiro che nano drug carrier, izvi zvichabatsira kutakurwa kwemishonga inorwisa kenza inobudiswa mubundu, kuvandudza maitiro e anti -kenza mishonga.
Polymer mamorekuru mumhinduro anogona kuumbwa otomatiki vesicle hollow spherical chimiro chepolymer, ine zvakanakira kugadzikana kwakasimba, kushanda kwakasiyana-siyana kunoshandiswa zvakanyanya semutakuri wezvinodhaka, asi, nekusiyana, senge mabhakitiriya uye hutachiona mune hunhu machubhu, tsvimbo. , uye izvo zvisiri spherical biological zvimiro zvinogona kuve nyore kupinda mumuviri. Nekuti mapolymer vesicles akaoma kuumba chimiro chisina kutenderera, izvi zvinomisa kugona kwepolymer kuendesa mishonga kwainoenda mumuviri wemunhu kusvika pamwero wakati.
Vatsvagiri vekuAustralia vakashandisa cryoelectron microscopy kuona shanduko yemapolymer mamorekuru mumhinduro. Vakaona kuti nekushandura huwandu hwemvura musolvent, chimiro uye saizi yepolymer vesicles inogona kugadziridzwa nekuchinja huwandu hwemvura musolvent.
Munyori anotungamira wekudzidza uye yunivhesiti yeNew South Wales Institute of chemistry yepine parr sol, akati: "Kubudirira uku kunoreva kuti tinogona kugadzira chimiro chepolymer vesicle chinogona kushanduka nenharaunda, senge oval kana tubular, uye package yezvinodhaka mairi." Humbowo hwekutanga hunoratidza kuti iyo yakasikwa, isiri-spherical nano-drug vatakuri vanogona kupinda mubundu maseru.
Tsvagiridzo iyi yakaburitswa pamhepo mune yazvino chinyorwa chejenari Nature Communications.
Nguva yekutumira: Mar-16-2018