Amaprotheni asanda kutholwa asekela ukucwengwa okusebenzayo kwe-Rare Earth

umthombo:izimayini

Ephepheni lakamuva elishicilelwe ku-Journal of Biological Chemistry, abacwaningi bakwa-ETH Zurich bachaza ukutholakala kwe-lanpepsy, iphrotheni ebopha ngokuqondile ama-lanthanides - noma izakhi zomhlaba eziyivelakancane - futhi iwabandlulula kwamanye amaminerali nezinsimbi.

Ngenxa yokufana kwawo namanye ama-ion ensimbi, ukuhlanzwa kwe-REE emvelweni kunzima futhi ukonga kuphela ezindaweni ezimbalwa. Ngokwazi lokhu, ososayensi banqume ukuhlola izinto zebhayoloji ezinemininingwane ephezulu yokubopha ama-lanthanides njengezindlela ezinganikeza indlela eya phambili.

Isinyathelo sokuqala kwakuwukubukeza izifundo zangaphambilini eziphakamisa ukuthi imvelo iye yashintsha amaprotheni ahlukahlukene noma ama-molecule amancane ukuze akhiphe ama-lanthanides. Amanye amaqembu ocwaningo athole ukuthi amagciwane athile, ama-methylotroph aguqula i-methane noma i-methanol, anama-enzyme adinga ama-lanthanides kumasayithi awo asebenzayo. Kusukela ekutholweni kokuqala kulo mkhakha, ukuhlonzwa kanye nokuhlukaniswa kwamaprotheni abandakanyeka ekuzweni, ekuthatheni nasekusetshenzisweni kwama-lanthanides, sekuphenduke umkhakha wocwaningo osafufusa.

Ukuhlonza abalingisi bamanoveli ku-lanthanome, u-Jethro Hemmann no-Philipp Keller kanye nabahlanganyeli abavela ku-D-BIOL kanye nelabhorethri ka-Detlef Günther e-D-CHAB, bahlole impendulo ye-lanthanide ye-methylotroph obligate Methylobacillus flagellatus.

Ngokuqhathanisa i-proteome yamangqamuzana akhule lapho ekhona futhi engekho i-lanthanum, bathola amaprotheni amaningana ayengahlobene ngaphambili nokusetshenziswa kwe-lanthanide.

Phakathi kwazo kwakukhona iphrotheni encane yokusebenza okungaziwa, iqembu manje eliyiqamba ngokuthi i-lanpepsy. Ukuchazwa kwe-in vitro kwephrotheni kwembule amasayithi okubopha ama-lanthanides anokucaciswa okuphezulu kwe-lanthanum ngaphezu kwe-calcium efana namakhemikhali.

I-Lanpepsy iyakwazi ukucebisa ama-lanthanides esixazululweni futhi ngaleyo ndlela ibambe amandla okuthuthukiswa kwezinqubo ze-bioinspired zokuhlanzwa okusimeme komhlaba ongavamile.

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Isikhathi sokuthumela: Mar-08-2023