I-Pregabalin 99% CAS 148553-50-8
Isingeniso:
| Igama Lekhemikhali: | I-Pregabalin |
| Omqondofana: | 3-(Aminomethyl) -5-methyl-hexanoic acid |
| Inombolo yeCas: | 148553-50-8 |
| I-Molecular Formula: | C8H17NO2 |
| Isisindo se-Molecular: | 159.23 |
| Isakhiwo samangqamuzana: |
-Inkomba Yekhwalithi Eyinhloko:
[Impahla]]: okuqinile okumhlophe okunjengekristalu.
[Okuqukethwe]]: ≥99.0%
[Ukuzungezisa okuqondile]]: [α]D20+9.5~+11.5o(C=1,H2O)
-Sebenzisa:
Isetshenziswa njenge-anticonvulsion, i-anti-epileptic drug.
-Incazelo
I-Pregabalin, emakethe ngaphansi kwegama lomkhiqizo i-Lyrica phakathi kwabanye, umuthi osetshenziselwa ukwelapha isithuthwane, ubuhlungu be-neuropathic, i-fibromyalgia, kanye nesifo sokukhathazeka okujwayelekile. Ukusetshenziswa kwaso ekwelapheni isithuthwane kunjengokwelashwa okungeziwe kokuquleka ingxenye noma ngaphandle kokujwayelekile kwesibili kubantu abadala. Okunye okusetshenziswa ngaphandle kwelebula kwe-pregabalin intermediate kufaka phakathi i-restless leg syndrome, ukuvimbela i-migraines, ukuphazamiseka kokukhathazeka komphakathi, nokuhoxiswa kotshwala. Uma isetshenziswa ngaphambi kokuhlinzwa ayibonakali isithinti ubuhlungu ngemva kokuhlinzwa kodwa ingase yehlise ukusetshenziswa kwama-opioid.
Imiphumela emibi evamile ihlanganisa: ukulala, ukudideka, inkinga yenkumbulo, ukungasebenzi kahle kwemoto, umlomo owomile, inkinga yokubona, nokuzuza isisindo. Imiphumela engemihle engase ibe yingozi ihlanganisa i-angioedema, ukusetshenziswa kabi kwezidakamizwa, kanye nokwanda kwengozi yokuzibulala. Lapho i-pregabalin intermediate ithathwa ngemithamo ephezulu isikhathi eside, ukulutheka kungase kwenzeke, kodwa uma kuthathwa imithamo evamile ingozi yokuba umlutha iphansi. Ihlukaniswa njenge-analogue ye-GABA.
U-Parke-Davis uthuthukise i-pregabalin intermediates njengongena esikhundleni se-gabapentin futhi walethwa emakethe ngu-Pfizer ngemuva kokuba inkampani ithole u-Warner-Lambert. Akumele kube khona inguqulo ejwayelekile etholakala e-United States kuze kube ngu-2018. Inguqulo ejwayelekile iyatholakala e-Canada nase-United Kingdom. E-US kubiza cishe i-300-400 USD ngenyanga. I-Pregabalin iyinto elawulwa kuSheduli V ngaphansi koMthetho Wezinto Ezilawulwayo ka-1970 (CSA).
