Pregabalin 99% CAS 148553-50-8
Intshayelelo:
| Igama leMchiza: | Pregabalin |
| Izithethantonye: | 3-(Aminomethyl) -5-methyl-hexanoic acid |
| Inombolo yeCas: | 148553-50-8 |
| Ifomula yeemolekyuli: | C8H17NO2 |
| Ubunzima beMolekyuli: | 159.23 |
| Ulwakhiwo lweMolekyuli: |
-Isalathisi soMgangatho oPhambili:
[Ipropathi]]: okuqinileyo okumhlophe okwekristale.
[Umxholo]]: ≥99.0%
[Ujikelezo olukhethekileyo]]: [α]D20+9.5~+11.5o(C=1,H2O)
-Sebenzisa:
Isetyenziswa njenge-anticonvulsion, i-anti-epileptic drug.
-Inkcazo
I-Pregabalin, ethengiswe phantsi kwegama le-brand Lyrica phakathi kwabanye, liyeza elisetyenziselwa ukunyanga isifo sokuxhuzula, iintlungu ze-neuropathic, i-fibromyalgia, kunye nokuphazamiseka kokuxhalabisa ngokubanzi. Ukusetyenziswa kwayo kwisifo sokuxhuzula njengonyango olongezelelekileyo lokuxhuzula ngokuyinxenye kunye okanye ngaphandle kokwenziwa ngokubanzi okwesibini kubantu abadala. Olunye usetyenziso olungekho ngeleyibhile lwe-pregabalin intermediates lubandakanya i-restless leg syndrome, uthintelo lwe-migraines, ukuphazamiseka koxinzelelo lwentlalo, kunye nokurhoxa kotywala. Xa isetyenziswe phambi kotyando ayibonakali ichaphazela intlungu emva kotyando kodwa inokunciphisa ukusetyenziswa kwe-opioids.
Iziphumo eziqhelekileyo ezichaphazelekayo ziquka: ukulala, ukudideka, inkathazo ngememori, ukulungelelaniswa kwemoto, umlomo owomileyo, ingxaki yombono, kunye nokuzuza ubunzima. Iziphumo ebezingalindelekanga ezimandundu ziquka i-angioedema, ukusetyenziswa kakubi kweziyobisi, kunye nokwanda komngcipheko wokuzibulala. Xa i-pregabalin intermediates ithathwa kwiidosi eziphezulu kwixesha elide, umlutha unokwenzeka, kodwa ukuba kuthathwe kwiidosi eziqhelekileyo umngcipheko wokuba likhoboka uphantsi. Ihlelwa njenge-analogue ye-GABA.
UParke-Davis uphuhlise i-pregabalin intermediates njengendlalifa ye-gabapentin kwaye yaziswa kwintengiso nguPfizer emva kokuba inkampani ifumene iWarner-Lambert. Akufuneki kubekho inguqulelo yegeneric ekhoyo eUnited States de kube ngu-2018. Inguqulelo yegeneric iyafumaneka eKhanada naseUnited Kingdom. E-US ixabisa malunga ne-300-400 USD ngenyanga. I-Pregabalin yinto elawulwayo yeShedyuli V phantsi koMthetho wezinto eziLawulwayo we-1970 (CSA).
